高能化學發表關于分子和超分子光化學、光生物學、輻射化學、等離子體化學、納米系統化學、新原子化學、光學信息系統和其他高能化學領域的工藝和材料。它在高能化學的所有領域發表理論和實驗研究，例如高能粒子與物質的相互作用，粒子和電磁輻射或熱原子對其氣態和冷凝狀態下的物質的作用所引起的短命物種的性質和反應性，以及由高能輻射在有機和無機系統中引發的化學過程。

High Energy Chemistry publishes original articles, reviews, and short communications on molecular and supramolecular photochemistry, photobiology, radiation chemistry, plasma chemistry, chemistry of nanosized systems, chemistry of new atoms, processes and materials for optical information systems and other areas of high energy chemistry. It publishes theoretical and experimental studies in all areas of high energy chemistry, such as the interaction of high-energy particles with matter, the nature and reactivity of short-lived species induced by the action of particle and electromagnetic radiation or hot atoms on substances in their gaseous and condensed states, and chemical processes initiated in organic and inorganic systems by high-energy radiation.