概述老化細(xì)胞的目標(biāo)是發(fā)表高質(zhì)量的，創(chuàng)新的研究解決衰老生物學(xué)的基本問(wèn)題。為了在《衰老細(xì)胞》雜志上發(fā)表，這項(xiàng)工作必須為理解衰老做出重大的新貢獻(xiàn)，并引起社會(huì)的普遍興趣。《衰老細(xì)胞》試圖涵蓋老年科學(xué)的所有領(lǐng)域，強(qiáng)調(diào)揭示衰老過(guò)程的機(jī)械方面的研究，以及衰老與年齡相關(guān)疾病之間的聯(lián)系。將考慮對(duì)沒(méi)有實(shí)質(zhì)力學(xué)見(jiàn)解的新老化過(guò)程的觀察，但對(duì)該領(lǐng)域應(yīng)具有特別高的影響。主題包括但不限于，營(yíng)養(yǎng)反應(yīng)信號(hào)通路，神經(jīng)和內(nèi)分泌信號(hào)通路，組織相互作用，遺傳和表觀遺傳調(diào)控和完整性，蛋白質(zhì)平衡，晝夜節(jié)律，活性氧和線粒體，細(xì)胞衰老，干細(xì)胞，progerias和干預(yù)，影響老化是鼓勵(lì)。所有的實(shí)驗(yàn)方法，包括植物模型，都是受歡迎的。關(guān)注特定年齡相關(guān)病理的發(fā)病機(jī)制的論文也很有趣，但應(yīng)該對(duì)衰老和疾病之間的基本聯(lián)系提供新的見(jiàn)解。目標(biāo)和范圍衰老細(xì)胞覆蓋:遺傳學(xué)和功能基因組學(xué):影響壽命的突變;基因的同源性;機(jī)體和細(xì)胞老化;基因操作。信號(hào)和基因表達(dá):與年齡相關(guān)的變化與表型和生理聯(lián)系的機(jī)制;胞內(nèi)信號(hào);細(xì)胞與組織的相互作用;激素、免疫和炎癥系統(tǒng)。細(xì)胞增殖、衰老與死亡:復(fù)制性衰老;細(xì)胞凋亡;端粒生物學(xué)等內(nèi)外因素的影響;時(shí)間細(xì)胞老化;老化細(xì)胞的表型。細(xì)胞應(yīng)激和損傷:自由基對(duì)細(xì)胞和組織的外在和內(nèi)在影響;自由基防御與損傷;自由基作為信號(hào)分子;壓力和衰老。干細(xì)胞與衰老:年齡對(duì)干細(xì)胞生成的影響遷移和體內(nèi)平衡;莖cell-niche交互;監(jiān)管機(jī)制。綜合生理學(xué):機(jī)體、細(xì)胞和分子水平衰老過(guò)程的結(jié)果。生物人口學(xué)與比較研究:人口與跨物種比較研究。老年與長(zhǎng)壽新理論:在已建立和新穎的老年與長(zhǎng)壽理論的最廣泛層面上的討論。《衰老細(xì)胞》創(chuàng)刊于2002年，雙月刊。文章類(lèi)型包括:新穎的，同行評(píng)審的研究，集中在上述領(lǐng)域。對(duì)近期備受矚目的研究進(jìn)行評(píng)估。評(píng)注對(duì)期刊或其他主要期刊上當(dāng)前特別重要的論文進(jìn)行評(píng)價(jià)的評(píng)注。生物老化一般理論的發(fā)展與批判。關(guān)鍵字衰老，衰老，長(zhǎng)壽，壽命，細(xì)胞衰老，細(xì)胞死亡，細(xì)胞凋亡，壓力，自由基，端粒酶，端粒，老年學(xué)，老年醫(yī)學(xué)抽象和索引信息學(xué)術(shù)檢索(EBSCO出版)學(xué)術(shù)搜索校友版(EBSCO出版)學(xué)術(shù)搜尋總理(EBSCO出版)CAS:化學(xué)文摘服務(wù)(ACS)CSA生物科學(xué)數(shù)據(jù)庫(kù)(ProQuest)Embase(愛(ài)思唯爾)InfoTrac(蓋爾Cengage)Ingenta選擇ISI提醒服務(wù)期刊引用報(bào)告/科學(xué)版(Clarivate Analytics)MEDLINE / PubMed(NLM)神經(jīng)科學(xué)抽象(它)ProQuest生物科學(xué)收藏(ProQuest)PubMed膳食補(bǔ)充劑子集(NLM)科學(xué)引文索引擴(kuò)展(Clarivate Analytics)

OverviewThe aim of Aging Cell is to publish the highest quality, innovative research addressing fundamental issues in the biology of aging. For publication in Aging Cell, the work must provide a major new contribution to the understanding of aging and be of general interest to the community. Aging Cell seeks to cover all areas of geroscience, highlighting research that uncovers mechanistic aspects of the aging process, as well as the links between aging and age-related disease. Observations of novel aging processes without substantial mechanistic insight will be considered, but should be of especially high impact for the field. Topics including, but not limited to, nutrient-responsive signaling pathways, neuronal and endocrine signaling pathways, tissue interactions, genetic and epigenetic regulation and integrity, proteostasis, circadian rhythms, ROS and mitochondria, cellular senescence, stem cells, progerias and interventions that affect aging are encouraged. All experimental approaches, including plant models, are welcome. Papers that focus on the pathogenesis of a specific age-related pathology are also of interest, but should offer new insights into the fundamental links between aging and disease.Aims and ScopeAging Cell covers:Genetics and functional genomics: mutations affecting longevity; gene homologies; organismal and cellular aging; gene manipulation.Signaling and gene expression: mechanisms linking age-associated changes with phenotypes and physiology; intracellular signaling; interactions between cells and tissues; hormonal, immune, and inflammatory systems.Cell proliferation, aging and death: replicative senescence; apoptosis; telomere biology and other intrinsic and extrinsic influences; chronological cellular aging; phenotypes of aging cells.Cell stress and damage: extrinsic and intrinsic influences of free radicals on cells and tissues; free radical defense and damage; free radicals as signaling molecules; stress and aging.Stem cells and aging: effects of age on stem cell generation; migration and homeostasis; stem cell-niche interactions; regulatory mechanisms.Integrative physiology: outcomes of aging processes at organismal, cellular and molecular levels.Biodemography and comparative studies: population and cross-species comparative studies.New theories of aging and longevity: discussion at the broadest level of established and novel theories of aging and longevity.Aging Cell was launched in 2002 and is published bimonthly. Article types include:Novel, peer-reviewed research, concentrating in the areas described above.Reviews and minireviews assessing high-profile recent research.Commentaries evaluating especially important current papers in the Journal or other leading journals.Development and criticism of general theories of biological aging.KeywordsAging, ageing, longevity, lifespan, cell senescence, cell death, apoptosis, stress, free radicals, telomerase, telomeres, gerontology, geriatric Abstracting and Indexing InformationAcademic Search (EBSCO Publishing)Academic Search Alumni Edition (EBSCO Publishing)Academic Search Premier (EBSCO Publishing)CAS: Chemical Abstracts Service (ACS)CSA Biological Sciences Database (ProQuest)Embase (Elsevier)InfoTrac (GALE Cengage)Ingenta SelectISI Alerting ServicesJournal Citation Reports/Science Edition (Clarivate Analytics)MEDLINE/PubMed (NLM)Neurosciences Abstracts (ProQuest)ProQuest Biological Science Collection (ProQuest)PubMed Dietary Supplement Subset (NLM)Science Citation Index Expanded (Clarivate Analytics)